BNU“京师学堂”脑科学前沿系列讲座第三十二讲
记忆和阿尔茨海默疾病的神经活动模式表征
Engram patterns: Content-specific representations in intracranial EEG and fMRI related to memory functions and Alzheimer's disease
主讲人：
Nikolai Axmacher 博士、教授
德国波鸿鲁尔大学心理学部认知神经所神经心理系
Head of the Department of Neuropsychology at the Institute of Cognitive Neuroscience, Ruhr University Bochum, Germany
Nikolai Axmacher博士，现任德国波鸿鲁尔大学心理学部认知神经所神经心理系主任。2005获得柏林洪堡大学医学博士学位，随后在德国波恩大学癫痫学系从事博士后研究员。2011年，成为癫痫学系Emmy Noether研究组长，担任德国神经退行性疾病中心(DZNE)的初级研究组组长。致力于记忆功能的神经机制研究，研究对象包括健康人群和阿尔茨海默症、PTSD等记忆障碍人群。近年来，他采用颅内脑电（iEEG），fMRI和EEG同步采集等方法对记忆的神经机制进行了系统且深入的研究，已在包括Science, Nature Neuroscience, Neuron, Nature Review Neuroscience, PNAS等国际脑科学期刊上发表SCI论文近130篇，被引用达5000余次。
摘要：Memory traces of specific events are not only found at the level of individual neurons, but also in “engram patterns” of larger brain networks. Using intracranial EEG recordings in epilepsy patients, we observed that engram patterns are reinstantiated during memory retrieval. Healthy participants showed that engram patterns are spontaneously replayed during awake resting state and sleep, suggesting a putative mechanism for memory consolidation. Analyzing content-specific representations may also be clinically relevant to identify early pathophysiology in Alzheimer’s disease. Using fMRI in genetic AD risk carriers for Alzheimer’s disease, we observed impaired entorhinal grid cell-like representations and altered navigational strategies. Together, these studies shed light on the neural basis of intact and disturbed content-specific representations in humans.
时间：2017年5月17日 （周三）上午10-12点
地点：北京师范大学 京师学堂大楼 第三学术报告厅（地下一层）
