人眼动控制机理的药理学和脑成像研究
Pharmacological and Neuroimaging Studies of Eye Movements in Humans
Ulrich Ettinger博士、教授
Department of Psychology, University of Bonn, Germany
德国波恩大学心理学系
Ettinger博士同时任英国伦敦大学国王学院精神医学、心理学和神经科学学院高级客座讲师。2002年获英国伦敦大学国王学院心理学和精神医学博士学位，之后在英国伦敦大学国王学精神医研究所、加拿大麦吉尔大学心理学部与道格拉斯医院从事博士后研究。2012年任德国波恩大学心理学系教授。Ettinger教授的研究主要从大脑结构、认知功能的行为和基因分析等方面研究认知精神药理学、人眼动控制及其精神分裂症的神经基础，已在Nature、Schizophrenia Bulletin、Journal of Neuroscience、Cerebral Cortex、NeuroImage等国际期刊上发表SCI论文120余篇，被引用达5800余次。
报告摘要：In the talk, the speaker will present work on the neural systems underlying eye movements in humans by drawing upon experimental pharmacological and functional neuroimaging approaches. Nicotine, an agonist at the nicotinic acetylcholine receptor, improves antisaccade performance and leads to reduced frontal eye field activation. Methylphenidate, a dopamine transporter blocker, improves smooth pursuit and improves the timing of predictive saccades. At the level of brain function, nicotine and methylphenidate show opposing effects in frontal eye field during smooth pursuit. Ketamine, an uncompetitive NMDA receptor antagonist used to model symptoms of schizophrenia, impairs smooth pursuit and reduces occipital and frontal activations. To conclude, (i) cognitive enhancers have beneficial effects on aspects of eye movement control, (ii) the ketamine model of psychosis is partly validated by oculomotor biomarkers, and (iii) oculomotor control is sensitive to alterations in the levels of acetylcholine, dopamine and glutamate.
时间：2017年6月15日 （周四）下午2-4点
地点：北京师范大学 京师学堂大楼 第三学术报告厅（地下一层）
