个体脑功能网络与个性化医学
Mapping Brain Functional Networks in Individuals for Personalized Medicine
Dr. Hesheng Liu, Associate Professor
Harvard Medical School, Massachusetts General Hospital
Dr. Hesheng Liu is an Associate Professor at Harvard Medical School and Director of the Laboratory For the Study of the Brain Basis of Individual Differences at Massachusetts General Hospital. He received his B.S., M.S., and Ph.D. degrees from Tsinghua University. His research focuses on developing novel neuroimaging and computational tools to reveal brain functional architecture in individual subjects. A major goal of his work is to localize functional networks in individual subjects to guide surgical intervention. Another theme in his lab is to identify personalized neuromodulation targets for brain disorders and study functional changes in individual patients after neuromodulation treatments. He has published over 60 papers in scientific journals including Nature Neuroscience, Neuron, PNAS, JAMA Psychiatry, etc.
Abstract
A major obstacle for exploring subtle aspects of network organization and translating insights into clinical applications is the lack of tools for mapping networks in individual subjects. We evaluated inter-individual variability in brain functional organization and developed a novel brain parcellation approach to accurately map functional regions at the individual level using resting-state fMRI. Based on the subject-specific functional regions, we were able to identify connectivity markers for cognitive ability in healthy subjects and clinical symptoms in various psychiatric disorders. These individually-identified functional circuits may lead to novel, personalized targets for neuromodulation treatments. Finally, I will briefly discuss our data on evaluating the effect of deep brain stimulation on individual patients’ functional networks.
邀请人：贺永教授、牛海晶教授
时间：2018年5月15日 上午10-12点
地点：北京师范大学京师学堂大楼第三会议室（地下室一层）
