讲座：Dr. Yuji Naya, 北京清华联合生命中心
03
2014-06
实验室邀请了北京清华联合生命中心的Dr. Yuji Naya做报告，欢迎感兴趣的老师和同学参加。
报告时间：4月3日下午3:40-5:10
报告地点：脑成像中心308会议室（大会议室）
报告题目：Semantic and episodic-like memory signals in the primate medial temporal lobe
报告摘要：
Declarative memory, which depends on the medial temporal lobe (MTL) structures, consists of two sub-categories: semantic memory and episodic memory. The former refers to general knowledge of facts, while the latter refers to memories of autobiographical events containing items, times and places. In this talk, I will present neurophysiological data examining the two memories in macaque brains. Semantic memory was tested using an item-item association task in which monkeys were required to retrieve a particular visual object when its paired object was presented as a cue stimulus. The single-unit data suggested that bidirectional signaling between the perirhinal cortex (PRC) of the MTL and visual association area TE is involved in the encoding and retrieval of item-item association memories of visual objects (Naya, Yoshida & Miyashita, 2001 & 2003). On the other hand, episodic memory was tested using a temporal-order memory task in which monkeys were required to encode two visual items and their temporal order. The data of single-unit recording indicated that the hippocampus (HPC) provided incremental timing signals from one item presentation to the next while the PRC signaled the conjunction of items and their relative temporal order. These results suggest the incremental timing signal in HPC is conveyed to PRC via the entorhinal cortex, where it is integrated with item information from TE and converted into a discrete item-based temporal order signal (Naya and Suzuki, 2011).
References
Naya Y., Yoshida M. and Miyashita Y. (2001) Backward Spreading of Memory-Retrieval Signal in the Primate Temporal Cortex. Science 291:661-664.
Naya Y., Yoshida M. and Miyashita Y. (2003) Forward processing of long-term associative memory in monkey inferotemporal cortex. J. Neurosci. 23: 2861-2871.
Naya Y. and Suzuki WA. (2011) Integrating what and when across the primate medial temporal lobe. Science 333: 773-776.
