北京师范大学认知神经科学与学习国家重点实验室

科研团队

在职教师

章晓辉 Ph.D.大脑可塑性与学习记忆的神经电生理机制 xhzhang#bnu.edu.cn http://brain.bnu.edu.cn/home/xhzhanglab/

教育经历

2000–2003　美国加州大学伯克利分校, HFSP博士后，导师：Mu-Ming Poo教授

1999–2000　美国加州大学圣地亚哥分校, 博士后；导师：Mu-Ming Poo教授

1994–1999　中国科学院上海生理研究所；神经生物学博士；导师：朱培闳教授

1990–1994　杭州大学（现浙江大学）生物系，生物学学士

工作经历

2018 –至今　北京师范大学 IDG/麦戈文脑科学研究院，研究员

2013 –至今　北京师范大学脑认知与学习国家重点实验室，教授，博士生导师

2007–2013　中国科学院神经科学研究所，研究员，课题组长，博士生导师

2003–2007　中国科学院神经科学研究所，副研究员，课题组组长

研究概述

大脑内神经元通过突触形成局部或长程神经环路，它们是大脑执行信息处理、学习、储存、以及生成指令的基本功能模块。我们课题组自2003年建立以来，一直致力于解析大脑皮层与海马神经环路的神经连接、功能特征、以及经验依赖的可塑性，重点研究皮层与海马参与感知觉加工、学习记忆等脑功能的神经环路机制。近七年内取得以下重要成果包括：（1）翔实解析了负责大脑关联学习的内嗅皮层→海马神经环路机制（Nature Neuroscience 2017；封面论文）；（2）揭示抑制性神经元环路调控大脑发育“关键期”可塑性的机制（Journal of Neuroscience 2014；Nature Communications 2014；Cell Reports 2016；Advanced Science 2020；Science Bulletin 2021）、以及调控神经网络特定时空电活动的工作机制（Neuron, 2017; 被Cell Press评为2017年中国年度五篇论文之一）；（3）解析神经元树突信息整合的计算规则（PLoS Computational Biology, 2014 & 2019; PNAS, 2019 & 2009）。实验室承担科技部973计划项目与国自然重点项目等研究课题。

发表文章

1. Zhang Y., Yao L., Li X., Meng M.Z., Shang Z.W., Wang Q., Xiao J., Gu X., Xu Z.H., Zhang X.H.* (2021) Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision. Sci. Bullet. 22:2225-2237. DOI: https://doi.org/10.1016/j.scib.2021.02.011.

2. Zhao Z.Q.^#, Shang Z.W.^#, Vasconcelos Z.^#, Li C.F.^#*, Jiang Y.S., Zu S.L., Zhang J.Y., Wang F.C., Yao L., Jung J.U., Brasil P., Moreira M.E., Qin C.F., Kerin T., Nielsen-Saines K.*, Cheng G.H.*, Zhang X.H.*, and Xu Z.H*. (2020) Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Adva. Sci. 7(18): 1901996, DOI:10.1002/advs.201901996.

3. Zhang Y., and Zhang X.H.* (2021) Portrait of visual cortical circuits for generating neural oscillation dynamics. Cogn. Neurodyn. 15(1): 3-16 (invited review).

4. Sun X.C., Bernstein M.J., Meng M.Z., Rao S.Y., Sørensen A.T., Yao L., Zhang X.H., Anikeeva P. O., and Li Y.X. (2020) Functionally distinct neuronal ensembles within the memory engram. Cell, 181(2): 410-423.

5. Ma X.Y., Zhang Y.Y., Wang L.N., Li N., Barkai E., Zhang X.H., Lin L.N., and Xu J.M. (2020) The firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors. J. Neurosci. 40 (18) 3591-3603.

6. Pi G.L., Gao D., Wu D.Q., Wang Y.L., Lei H.Y., Zeng W.B., Gao Y., Yu H.L., Xiong R., Jiang T., Li S.H., Wang X., Guo J., Zhang S., Yin T.Y., He T., Ke D., Li R.N., Li, H.L., Liu G.P., Yang Y.F., Luo M.H., Zhang X.H., Yang Y., and Wang Z.J. (2020) Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat. Commun. 11, 183, https://doi.org/10.1038/s41467-019-13919-3.

7. Li S.T., Liu N. Zhang X.H.*, McLaughlin D.*, Zhou D.*, and Cai D. (2019) Dendritic computations captured by an effective point neuron model. Proc. Natl. Acad. Sci. USA 116 (30): 15244-15252.

8. Li S.T., Liu N., Yao L., Zhang X.H.*, Zhou D.*, and Cai D. (2019) Determination of effective synaptic conductances using somatic voltage clamp. PLoS Comput. Biol. 15(3):e1006871 https://doi.org/10.1371/journal.pcbi.1006871.

9. Li X., Li Y.D., Zhang J.H.*, and Zhang X.H.* (2019) Selective targeting of perirhinal cortex projection to hippocampal CA1 interneurons. Neurosci. Bullet. 35: 763-765.

10. Wang S.#, Tan N.D.#, Zhu X.L., Yao M.H., Zhang X.H.*, and Xu Z.H.* (2018) Sh3rf2 haploinsufficiency leads to unilateral neuronal development deficits and autistic-like behaviors in mice. Cell Rep. 25: 2963-2971, https://doi.org/10.1016/j.celrep.2018.11.044.

11. Chen G., Zhang Y., Li X., Zhao X.C., Ye Q., Lin Y.X., Tao H.Z., Rasch M.J.*, and Zhang X.H.* (2017) Distinct inhibitory circuits orchestrate cortical beta and gamma band oscillations. Neuron 96: 1403–1418 (selected as Cell Press Paper of the Year 2017-China, one of the 5 papers in the Life Science Research).

12. Li Y.D., Xu J.M., Liu Y.F., Zhu J., Liu N., Zeng W.B., Huang N., Rasch M.J., Jiang H.F., Gu X., Li X., Luo M.H., Li C.Y., Teng J.L., Chen J.G., Zeng S.Q., Lin L.N., and Zhang X.H.* (2017) A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nat. Neurosci. 20:559–570 (The cover story).

13. Miao Q.L., Yao L., Malte J.R., Ye Q., Li X. and Zhang X.H.* (2016) Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset. Cell Rep. 16, 1677–1689, http://dx.doi.org/10.1016/j.celrep.2016.07.013.

14. Liu Y.G.^#, Miao Q.L.^#, Yuan J.C, Rao Z.P., Ye Q., Geng J.L., Zhang. X.H.*, and Cheng L.P.* (2015) Ascl1 converts dorsal midbrain astrocytes into functional neurons in vivo. J. Neurosci. 35(25): 9336-9355 (^#: equal contribution).

15. Chen G., Rasch M.J., Wang R. and Zhang X.H.* (2015) Experience-dependent emergence of beta and gamma band oscillations in the primary visual cortex during the critical period. Sci Rep. 5, 17847; doi: 10.1038/srep17847.

16. He L.J., Liu N., Chen T.L., Chen X.J., Li Y.D., Shu Y.S., Qiu Z.L., and Zhang X.H.* (2014) Conditional deletion of MeCP2 in parvalbumin-expressing GABAergic cells results in absence of critical period plasticity. Nat. Commun. 5:5036 doi: 10.1038/ncomms6036.

17. Chen X.J., Rasch M., Chen G., Wu S., and Zhang X.H.* (2014) Binocular input coincidence mediates the critical period plasticity of developing mouse visual cortex. J. Neurosci. 34(8): 2940-2955.

18. Wang J.Y., Chen F., Fu X.Q., Ding C.S., Zhou L., Zhang X.H., and Luo Z.G.* (2014) Caspase-3 cleavage of dishevelled induces elimination of postsynaptic structures. Dev. Cell 28, 670–684.

19. Meng F.X., Chen S.Y., Miao Q.L., Zhou K.C., Lao Q.C., Zhang X.H., Guo W.Y., Jiao J.W. (2012) Induction of fibroblasts to neurons through adenoviral gene delivery. Cell Res. 22:436–440.

20. Zhang X.H., Bi G. Q, and Duan S.M, (2012) Progress of the neural plasticity researches in China. In “Neuroscience section – Annual Review of Biological Sciences in China”; Scientific Press: Beijing, pp: 107-123. (in Chinese).

21. Gong L.Q., He L.J., Dong Z.Y., Lu X.H., Poo M.M.*, and Zhang X.H.* (2011) Post-induction requirement of NMDA receptor activation for late phase long-term potentiation of developing retinotectal synapses in vivo. J. Neurosci. 31: 3328-3335.

22. Zhang X.H.*, and Poo M.M. (2010) Progress in neural plasticity (in China). Sci. China Life Sci. 53: 322-329. (Invited review in the special issue: Neuroscience in China 2000-2009)

23. Ye C.Q., Poo M. M., Dan Y.* and Zhang X.H.* (2010) Synaptic mechanisms of direction selectivity in primary auditory cortex. J. Neurosci. 30: 1861-1868.