北京师范大学认知神经科学与学习国家重点实验室

科研团队

在职教师

吴　倩 Ph.D.脑发育的细胞和分子机制；脑类器官技术；脑疾病的机制解析与干预 qianwu#bnu.edu.cn

教育经历

2003.08－2008.04 美国匹兹堡大学生物系，博士学位

1999.09－2003.07 北京师范大学生命科学学院，学士学位

工作经历

2018.10－今，北京师范大学，认知神经科学与学习国家重点实验室，教授
北京师范大学IDG/麦戈文脑科学研究院，研究员

2018.01－2018.09，中国科学院生物物理研究所，研究员

2011.10－2017.12，中国科学院生物物理研究所，副研究员

2008.05－2011.09，美国匹兹堡大学医学院病理系，博士后

研究概述

吴倩课题组长期致力于脑发育与疾病机制解析及类器官体外构建研究。主要研究方向包括：（1）脑发育的细胞与分子机制：研究神经干细胞增殖、分化与谱系命运决定，解析不同脑区细胞类型产生、空间特化及神经环路形成的发育规律与分子调控机制；（2）脑类器官构建与技术创新：基于人脑发育规律，构建脑区特异性及跨脑区复合类器官模型，在体外重建人脑发育的关键过程、细胞微环境及神经环路；（3）脑疾病机制解析与干预：结合患者样本、脑类器官和模式动物，解析脑发育障碍等疾病的细胞与分子机制，鉴定关键致病细胞类型、基因及信号通路，并探索针对性的干预与治疗策略。相关成果发表在 Nature、Science、Cell、Nature Neuroscience、Cell Stem Cell、Cell Research 等期刊，获国家自然科学奖二等奖、北京市科学技术（自然科学奖）一等奖和二等奖。研究成果入选“2020年度中国生命科学十大进展”和“2024年度中国神经科学重大进展”，并获国家发明专利授权4项。

发表文章

1. Zhang J, Li M, Wang M, Sun Y, Yin C, Yang S, Wang B, Liu Z, Wang W, Liu M, Zhao Y, Zhou X, Cai L^#, Zhong S^#, Wang X^#, Wu Q^#. Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex. Nature Neuroscience 2026 Mar;29(3):746-758. doi: 10.1038/s41593-025-02150-7.

2. Zhang L, Yu M, Chen G, Ge S, Wang M, Zhang X, Zhao M, Gu H, Huang M, Liu A, Ran G, Liu Z, Liao T, Chen Q, Miao C, Lu Y, Wang Y, Wang F, Liu Z, Zhu H, Wu Q^#, Zhou Z^#, Xiong W^#, Wang X^#, Cao P^#. Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain. Cell. 2026 Apr 2;189(7):2108-2127.e21. doi: 10.1016/j.cell.2026.01.035.

3. Zhang C, Zou Y, Zhuo L, Liu X, Zhong S, Yin C, Li M, Wang M, Wang W, Zhou X, Zeng B, Dong C, Sun L^#, Wang Z^#, Li A^#, Wu Q^#, Wang X^#. Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks. Nature Communications 2026 Apr 18. doi: 10.1038/s41467-026-71923-w.

4. Lu T, Wang M, Zhou W, Ni Q, Yue Y, Wang W, Shi Y, Liu Z, Li C, Hong B, Zhou X, Zhong S, Wang K, Zeng B, Zhang J, Wang W, Zhang X^#, Wu Q^#,Wang X^#. Decoding transcriptional identity in developing human sensory neurons and organoid modeling. Cell. 2024 Dec 26;187(26):7374-7393.e28. doi: 10.1016/j.cell.2024.10.023.

5. Shi Y^#, Huang L, Dong H, Yang M, Ding W, Zhou X, Lu T, Liu Z, Zhou X, Wang M, Zeng B, Sun Y, Zhong S, Wang B, Wang W, Yin C, Wang X^#, Wu Q^#. Decoding the spatiotemporal regulation of transcription factors during human spinal cord development. Cell Research. 2024 Mar;34(3):193-213. doi: 10.1038/s41422-023-00897-x.

6. Zhong S^#, Wang M, Huang L, Chen Y, Ge Y, Zhang J, Shi Y, Dong H, Zhou X, Wang B, Lu T, Jing X, Lu Y, Zhang J, Wang X, Wu Q^#. Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development. Nature Communications 2023 Nov 22;14(1):7613. doi: 10.1038/s41467-023-43568-6.

7. Zeng B, Liu Z, Lu Y, Zhong S, Qin S, Huang L, Zeng Y, Li Z, Dong H, Shi Y, Yang J, Dai Y, Ma Q, Sun L, Bian L, Han D, Chen Y, Qiu X, Wang W, Marín O^#, Wu Q^#,Wang Y^#, Wang X^#. The single-cell and spatial transcriptional landscape of human gastrulation and early brain development. Cell Stem Cell. 2023 Jun 1;30(6):851-866.e7. doi: 10.1016/j.stem.2023.04.016. (Cover Story)

8. Yu B, Zhang Q, Lin L, Zhou X, Ma W, Wen S, Li C, Wang W, Wu Q^#, Wang X^#, Li XM^#. Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling. Cell Discovery. 2023 Feb 14;9(1):19. doi: 10.1038/s41421-022-00506-y.

9. Wang W, Wang M, Yang M, Zeng B, Qiu W, Ma Q, Jing X, Zhang Q, Wang B, Yin C, Zhang J, Ge Y, Lu Y, Ji W, Wu Q^#, Ma C^#, Wang X^#. Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans. Cell Research. 2022 Aug;32(8):729-743. doi: 10.1038/s41422-022-00678-y.

10. Zhou X, Lu Y, Zhao F, Dong J, Ma W, Zhong S, Wang M, Wang B, Zhao Y, Shi Y, Ma Q, Lu T, Zhang J^#, Wang X^#, Wu Q^#. Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development. Cell Stem Cell. 2022 Feb 3;29(2):328-343. doi: 10.1016/j.stem.2021.11.009.

11. Shi Y, Wang M, Mi D, Lu T, Wang B, Dong H, Zhong S, Chen Y, Sun L, Zhou X, Ma Q, Liu Z, Wang W, Zhang J, Wu Q^#, Marín O^#, Wang X^#. Mouse and human share conserved transcriptional programs for interneuron development. Science. 2021 Dec 10;374(6573):eabj6641. doi: 10.1126/science.abj6641.

12. Zhang Q, Cheng S, Wang Y, Wang M, Lu Y, Wen Z, Ge Y, Ma Q, Chen Y, Zhang Y, Cao R, Li M, Liu W, Wang B, Wu Q^#, Jia W^#, Wang X^#. Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages. Nature Communications. 2021 Nov 25;12(1):6867. doi: 10.1038/s41467-021-27018-9.

13. Xie Z, Wang M, Liu Z, Shang C, Zhang C,Sun L, Gu H, Ran G, Pei Q, Ma Q, Huang M, Zhang J, Lin R, Zhou Y, Zhang J, Zhao M, Luo M, Wu Q^#, Cao P^#, Wang X^#. Transcriptomic encoding of sensorimotor transformation in the midbrain. Elife.2021 Jul 28;10:e69825. doi: 10.7554/eLife.69825.

14. Yi W, Lu Y, Zhong S, Zhang M^#, Sun L, Dong H, Wang M, Wei M, Xie H, Qu H, Peng R, Hong J, Yao Z, Tong Y, Wang W, Ma Q, Liu Z, Ma Y, Li S, Yin C, Liu J, Ma C, Wang X^#, Wu Q^#, Xue T^#. A single-cell transcriptome atlas of the aging human and macaque retina. National Science Review, 2021 April;8(4): nwaa179, doi.org/10.1093/nsr/nwaa179

15. Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X^#, Wu Q^#. Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2021 Mar;64(3):419-433. doi: 10.1007/s11427-020-1767-5.

16. Shi Y, Sun L, Wang M, Liu J, Zhong S, Li R, Li P, Guo L, Fang A, Chen R, Ge WP, Wu Q^#, Wang X^#. Vascularized human cortical organoids (vOrganoid) model cortical development in vivo. Plos Biology. 2020; May 13;18(5).

17. Yin C, Zhou X, Yao Y, Wang W^#, Wu Q^#, Wang X^#. Abundant self-amplifying intermediate progenitors in the subventricular zone of the Chinese tree shrew neocortex. Cerebral Cortex. 2020 May 14;30(5):3370-3380.

18. Zhong S, Ding W, Sun L, Lu Y, Dong H, Fan X, Liu Z, Chen R, Zhang S, Ma Q, Tang F, Wu Q^#, Wang X^#. Decoding the development of the human hippocampus. Nature. 2020 Jan;577(7791):531-536. doi: 10.1038/s41586-019-1917-5.