State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University

Faculty

Current Faculty

Bing Liu Ph.D.Research on brain development and brain diseases based on multi-modal brain imaging and multi-omics techniques bing.liu#bnu.edu.cn

Educational Experience

2002.09-2007.07, Institute of Automation, Chinese Academy of Sciences，Ph.D. in Pattern Recognition and Intelligent System

1998.09-2002.07, Civil Aviation University of China， B.E. in Automation

Professional Experience

2021.02-now, Beijing Normal University, Professor, Principal Investigator, PhD Student Advisor

2020.09-now, Chinese Institute for Brain Research, CIBR Scholar

2016.05-2021.02, CAS Center for Excellence in Brain Science and Intelligence Technology，Principal Investigator

2015.11-2021.02, Institute of Automation, Chinese Academy of Sciences， Professor, Principal Investigator, PhD Student Advisor

2010.11-2015.10, Institute of Automation, Chinese Academy of Sciences，Associate Professor, Young Principal Investigator, MA Student Advisor

2007.07-2010.10, Institute of Automation, Chinese Academy of Sciences，Assistant Professor

Research Description

The research interests of Prof. Bing Liu’s Lab mainly focus on the two topics : (1) Clinical translation of multi-modal neuroimaging: here we attempt to build clinical useful biomarkers for brain disorders by integrating multi-modal neuroimaging and other omics data, and using novel artificial intelligence technologies. The objective of these studies is to identify quantitative, individualized, generalized and clinically useful imaging biomarkers for the precision diagnosis and personalized treatment of brain disorders, especially for various psychiatric disorders. (2) Neuroscience translation of multi-modal data: By combing genome, transcriptome, multi-modal neuroimaging and other data, we attempt to study the heritability of brain networks, the connection between brain networks and genetic variations, to find key genes modulating hub brain regions and important brain connectivity, and finally to reveal the underlying genetic and neural mechanisms of the individual differences in human neurodevelopment, behaviors or brain disorders and to construct dynamic prediction models of individual performance. Our lab has published over 70 research papers in peer-reviewed journals, including Nature Medicine, Journal of Neuroscience, Schizophrenia Bulletin, Neuropsychopharmacology, NeuroImage etc.

Publications

1. Qi Wang, Ke Hu, Meng Wang, Yuxin Zhao, Yong Liu, Lingzhong Fan, Bing Liu*. Predicting brain age during typical and atypical development based on structural and functional neuroimaging. Human Brain Mapping. 2021; In press.

2. Ang Li; Andrew Zalesky; Weihua Yue; Oliver Howes; Hao Yan; Yong Liu; Lingzhong Fan; Kirstie J Whitaker; Kaibin Xu; Guangxiang Rao; Jin Li; Shu Liu; Meng Wang; Yuqing Sun; Ming Song; Peng Li; Jun Chen; Yunchun Chen; Huaning Wang; Wenming Liu; Zhigang Li; Yongfeng Yang; Hua Guo; Ping Wan; Luxian Lv; Lin Lu; Jun Yan; Yuqing Song; Huiling Wang; Hongxing Zhang; Huawang Wu;Yuping Ning; Yuhui Du; Yuqi Cheng; Jian Xu; Xiufeng Xu; Dai Zhang; Xiaoqun Wang; Tianzi Jiang*; Bing Liu*; A neuroimaging biomarker for striatal dysfunction in schizophrenia, Nature Medicine, 2020, 26: 558-565.

3. Shu Liu; Ang Li; Yong Liu; Hao Yan; Meng Wang; Yuqing Sun; Lingzhong Fan; Ming Song; Kaibin Xu; Jun Chen; Yunchun Chen; Huaning Wang; Hua Guo; Ping Wan; Luxian Lv; Yongfeng Yang; Peng Li; Lin Lu; Jun Yan; Huiling Wang; Hongxing Zhang; Huawang Wu;Yuping Ning; Dai Zhang; Tianzi Jiang; Bing Liu*; Polygenic effects of schizophrenia on hippocampal gray matter volume and hippocampus-medial prefrontal cortex functional connectivity in a large sample of Han Chinese population, British Journal of Psychiatry, 2019, 6:1-8.

4. Shu Liu; Ang Li; Yong Liu; Jin Li; Meng Wang; Yuqing Sun; Wen Qin; Chunshui Yu; Tianzi Jiang; Bing Liu*; MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex., Psychological Medicine, 2019, 26:1-9.

5. Jin Li^#, Xiaolong Zhang^#, Ang Li, Shu Liu, Wen Qin, Chunshui Yu, Yong Liu, Bing Liu^*, Tianzi Jiang^*. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations. Neurobiology of Aging. 2018; 64:116-122.

6. Bing Liu; Xiaolong Zhang; Yue Cui; Wen Qin; Yan Tao; Ji Li; Chunshui Yu; Tianzi Jiang^*; Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations, Schizophrenia Bulletin, 2017, 43(3): 673-680.

7. Tianqi Wang^(#)，Xiaolong Zhang^(#)，Ang Li，Meifang Zhu，Shu Liu，Wen Qin，Jin Li，Chunshui Yu，Tianzi Jiang，Bing Liu^(*)，Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations，NeuroImage: Clinical，2017.01.01，14：441~449.

8. Yue Cui^#, Bing Liu^#, Yuan Zhou, Lingzhong Fan, Jin Li, Yun Zhang, Huawang Wu, Bing Hou, Chao Wang, Fanfan Zheng, Chengxiang Qiu, Li-Lin Rao, Yuping Ning, Shu Li, Tianzi Jiang*. Genetic Effects on Fine-Grained Human Cortical Regionalization. Cerebral Cortex. 2016; 26(9):3732-43.

9. Xiaolong Zhang, Jin-tai Yu, Jin Li, Chao Wang, Lan Tan, Bing Liu*, Tianzi Jiang*. Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume and Functional Connectivity in Young Healthy Individuals. Neuropsychopharmacology. 2015;40(7):1794-803.

10. Bing Liu^#, Lingzhong Fan^#, Yue Cui, Xiaolong Zhang, Bing Hou, Yonghui Li, Wen Qin, Dawei Wang, Chunshui Yu^*, Tianzi Jiang^*. DISC1 Ser704Cys impacts thalamic-prefrontal connectivity. Brain Structure & Function. 2015;220(1):91-100.

11. Yan Tao, Bing Liu*, Xiaolong Zhang, Jin Li, Wen Qin, Chunshui Yu, Tianzi Jiang. The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety. Frontiers in Neuroanatomy. 2015; 9:152.

12. Jin Li^#, Bing Liu^#, Chuansheng Chen, Yue Cui, Liqing Shang, Yun Zhang, Chao Wang, Xiaolong Zhang, Qinghua He, Wen Zhang, Wenwei Bi, Tianzi Jiang*. RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory. Human Brain Mapping. 2015; 36(11):4372-82.

13. Chao Wang^#, Bing Liu^#, Haixia Long, Linzhong Fan, Jin Li, Xiaolong Zhang, Chengxiang Qiu, Chunshui Yu, Tianzi Jiang*. Epistatic interaction of BDNF and COMT on the frontostriatal system. Neuroscience. 2015; 298:380-8.

14. Bing Liu, Xiaolong Zhang, Bing Hou, Jin Li, Chengxiang Qiu, Wen Qin, Chunshui Yu^*, Tianzi Jiang^*. The impact of MIR137 on dorsolateral prefrontal-hippocampal functional connectivity in healthy subjects. Neuropsychopharmacology. 2014;39(9):2153-60.

15. Chao Wang^#, Yuanchao Zhang^#, Bing Liu^#, Haixia Long, Chunshui Yu, Tianzi Jiang^*. Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity. The Journal of Neuroscience. 2014;34(7):2645-51.

16. Haixia Long^#, Bing Liu^#, Bing Hou, Chao Wang, Keith M. Kendrick, Chunshui Yu^*, Tianzi Jiang^*. A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network. Chinese Science Bulletin. 2014;59(13):1355-61.

17. Yonghui Li^#, Bing Liu^#, Bing Hou^#, Wen Qin, Dawei Wang, Chunshui Yu^*, Tianzi Jiang^*. Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI. Cerebral Cortex. 2013;23(7):1715-23.

18. Geng Chen, Chengxiang Qiu, Qipeng Zhang, Bing Liu^*, Qinghua Cui^*. Genome-wide analysis of human SNPs at long intergenic noncoding RNAs. Human Mutation. 2013;34(2):338-44.

19. Dawei Wang^#, Bing Liu^#, Wen Qin, Junping Wang, Yunting Zhang, Tianzi Jiang, Chunshui Yu^*. KIBRA gene variants are associated with synchronization within the default-mode and executive control networks. NeuroImage. 2013;69:213-22.

20. Haixia Long^#, Bing Liu^#, Bing Hou, Chao Wang, Jin Li, Wen Qin, Dawei Wang, Yuan Zhou, Keith M. Kendrick, Chunshui Yu^*, Tianzi Jiang^*. The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala. Neuroscience Bulletin. 2013;29(1):4-15.