State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University

Faculty

Current Faculty

Yaojing Chen Ph.D.Cognitive aging and cognitive impairment chenyaojing#bnu.edu.cn https://www.researchgate.net/profile/Yaojing-Chen-2 https://scholar.google.com/citations?user=m4TdGA0AAAAJ&hl=zh-CN

Educational Experience

PhD in Cognitive Neuroscience, Beijing Normal University, Sep.2011- Jun.2016

B.S. in Intelligence Science and Technology, Beijing University of Posts and Telecommunications, Sep.2007-Jun.2011

Professional Experience

Associate professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Jul.2021-present

Assistant professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Jun.2016-Jul.2021

Postdoctoral faculty, Faculty of Geography, Beijing Normal University, Jun.2016-Jun.2018

Research Description

My research interests focus on cognitive function and brain change in elderly with risk gene or other risk factors of Alzheimer’s disease, especially APOE gene and elderly chronic disease.

Publications

1. Chao Du, Xin Li, Jingyi Li, Wenxu Wang, Mingxi Dang, Jiayin Cheng, Kai Xu, Jun Wang, Chuansheng Chen,Yaojing Chen& Zhanjun Zhang. Leisure activities as reserve mediators of the relationship between loneliness and cognition in aging. Transl Psychiatry 14, 217 (2024).

2. Feng Sang, Shaokun Zhao, Zilin Li, Yiru Yang, Yaojing Chen, Zhanjun Zhang. Cortical thickness reveals sex differences in verbal and visuospatial memory[J]. Cerebral Cortex, 2024, 34(3): bhae067.

3. Lingling Ding, Hao Liu, Jing Jing, Yong Jiang, Xia Meng, Yaojing Chen, Xingquan Zhao, Haijun Niu, Tao Liu, Yongjun Wang, Zixiao Li. Lesion network mapping for neurological deficit in acute ischemic stroke. Annals of Neurology, 2023,94(3), 572-584.

4. Chao Du; Mingxi Dang; Kewei Chen; Yaojing Chen; Zhanjun Zhang; Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI, Alzheimer's Research Therapy, 2023, 15(199): 1-11

5. Bolong Wang, Yaojing Chen, Kewei Chen, Hui Lu, Zhanjun Zhang. From local properties to brain‐wide organization: A review of intraregional temporal features in functional magnetic resonance imaging data[J]. Human Brain Mapping, 2023, 44(9): 3926-3938.

6. Yiru Yang; Yaojing Chen; Feng Sang; Shaokun Zhao; Jun Wang; Xin Li; Chuansheng Chen; Kewei Chen; Zhanjun Zhang; Successful or pathological cognitive aging? converging into a ‘‘frontal preservation, temporal impairment (FPTI)” hypothesis, Science Bulletin, 2022, 67(22): 2285-2290

7. Mingxi Dang; Qian Chen; Xiaobin Zhao; Kewei Chen; Xin Li; Junying Zhang; Jie Lu; Lin Ai; Yaojing Chen; Zhanjun Zhang ; Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease, Human Brain Mapping, 2022, 44(2): 327-340

8. Yiru Yang, Yaojing Chen, Caishui Yang, Kewei Chen, Xin Li, Zhanjun Zhang. Contributions of early-life cognitive reserve and late-life leisure activity to successful and pathological cognitive aging[J]. BMC geriatrics, 2022, 22(1): 831.

9. Chen Yaojing, Dang Mingxi, Zhang Zhanjun. Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and –specific lesion patterns[J]. Molecular Neurodegeneration, 2021, 16(1).

10. Sang Feng, Chen Yaojing, Chen Kewei, Dang Mingxi, Gao Shudan, Zhang Zhanjun. Sex Differences in Cortical Morphometry and White Matter Microstructure During Brain Aging and Their Relationships to Cognition. Cerebral Cortex. 2021 Jun. DOI: 10.1093/cercor/bhab155.

11. Chao Du, Yaojing Chen, Kewei Chen, Zhanjun Zhang. Disrupted anterior and posterior hippocampal structural networks correlate impaired verbal memory and spatial memory in different subtypes of mild cognitive impairment[J]. European Journal of Neurology, 2021, 28(12): 3955-3964.

12. Caishui Yang, Xin Li, Junying Zhang, Yaojing Chen, He Li, Dongfeng Wei, Peng Lu, Ying Liang, Zhen Liu, Ni Shu, Fang Wang, Qing Guan, Wuhai Tao, Qingshan Wang, Jianjun Jia, Lin Ai, Ruixue Cui, Yanping Wang, Dantao Peng, Wei Zhang, Kewei Chen, Xiaomin Wang, Jizong Zhao, Yongyan Wang, Qi Dong, Jun Wang, Zhanjun Zhang, Beijing Aging Brain Rejuvenation Initiative workgroup; Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative[J]. Alzheimer's and Dementia, 2021(1).

13. Sun Jinping; Zhu Zhibao; Chen Kewei; Wei Dongfeng; Li Xin; Li He; Zhang Junying; Chen Xiaochun*; Chen Yaojing*; Zhang Zhanjun*; APOE epsilon 4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly, Aging-US, 2020, 12(12): 12019-12031.

14. Weiyi Zeng; Yaojing Chen; Zhibao Zhu; Shudan Gao; Jianan Xia; Xiaochun Chen*; Jianjun Jia*; Zhanjun Zhang; Severity of white matter hyperintensities: Lesion patterns, cognition, and microstructural changes, Journal of Cerebral Blood Flow & Metabolism, 2020, 40(12): 2454-2463.

15. Chen Yaojing; Lv Chenlong; Li Xin; Zhang Junying; Chen Kewei; Liu Zhongwan; Li He; Fan Jialing; Qin Ting; Luo Liang; Zhang Zhanjun; The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging , Aging-US, 2019, 11(14): 4923-4942.

16. Yang Yiru; Chen Yaojing; Chen Kewei; Wei Dongfeng; Li Peng; Zeng Weiyi; Pei Jing; Mao Haohao; Jia Jianjun; Chang Zhanjun; Increased intrinsic connectivity for structural atrophy and functional maintenance after acute ischaemic stroke , European Journal of Neurology, 2019, 26(6): 935-942.

17. Chen Yaojing; Qi Di; Qin Ting; Chen Kewei; Ai Meishan; Li Xin; Li He; Zhang Junying; Mao Haohao; Yang Yiru; Zhang Zhanjun; Brain Network Connectivity Mediates Education-related Cognitive Performance in Healthy Elderly Adults , Current Alzheimer Research, 2019, 16(1): 19-28.

18. Fan, Jialing; Tao, Wuhai; Li, Xin; Li, He; Zhang, Junying; Wei, Dongfeng; Chen, Yaojing; Zhang, Zhanjun; The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk, International Journal of Molecular Sciences, 2019, 20(5)(1177): 1-31.

19. Gao, Shudan; Chen, Yaojing; Sang, Feng; Yang, Yiru; Xia, Jianan; Li, Xin; Zhang, Junying; Chen, Kewei; Zhang, Zhanjun; White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes, Diabetes, 2019, 68(11): 2085-2094.

20. Chen, Yaojing; Liu, Zhen; Zhang, Junying; Chen, Kewei; Yao, Li; Li, Xin; Gong, Gaolang; Wang, Jun; Zhang, Zhanjun; Precuneus degeneration in nondemented elderly individuals with APOE varepsilon4: Evidence from structural and functional MRI analyses, Hum Brain Mapp, 2017, 38(1): 271-282.

21. Chen, Yaojing; Wang, Ailin; Tang, Jinfu; Wei, Dongfeng; Li, Peng; Chen, Kewei; Wang, Yongyan; Zhang, Zhanjun; Association of White Matter Integrity and Cognitive Functions in Patients With Subcortical Silent Lacunar Infarcts, Stroke, 2015, 46(4): 1123-1126.

22. Chen, Yaojing; Li, Peng; Gu, Bin; Liu, Zhen; Li, Xin; Evans, Alan C; Gong, Gaolang; Zhang, Zhanjun; The effects of an APOE promoter polymorphism on human cortical morphology during nondemented aging, Journal of Neuroscience, 2015, 35(4): 1423-1431.

23. Chen, Yaojing; Chen, Kewei; Zhang, Junying; Li, Xin; Shu, Ni; Wang, Jun; Zhang, Zhanjun; Reiman, Eric M.; Disrupted Functional and Structural Networks in Cognitively Normal Elderly Subjects with the APOE epsilon 4 Allele, Neuropsychopharmacology, 2015, 40(5): 1181-1191.

24. Chen, Yaojing; Liu, Zhen; Zhang, Junying; Tian, Guihua; Li, Linzi; Zhang, Sisi; Li, Xin; Chen, Kewei; Zhang, Zhanjun; Selectively Disrupted Functional Connectivity Networks in Type 2 Diabetes Mellitus, Frontiers in Aging Neuroscience, 2015, 7(233): 1-0.

25. Chen, Yaojing; Liu, Zhen; Zhang, Junying; Xu, Kai; Zhang, Sisi; Wei, Dongfeng; Zhang, Zhanjun; Altered Brain Activation Patterns Under Different Working Memory Loads in Patients With Type 2 Diabetes, Diabetes Care, 2014, 37(12): 3157-3163.

26. Chen, Yaojing; Wang, Jun; Zhang, Junying; Zhang, Ting; Chen, Kewei; Fleisher, Adam; Wang, Yongyan; Zhang, Zhanjun; Aberrant functional networks connectivity and structural atrophy in silent lacunar infarcts: relationship with cognitive impairments., Journal of Alzheimer's Disease, 2014, 42(3):841-850.

27. Chen, Yaojing; Liu, Zhen; Wang, Ailin; Zhang, Junying; Zhang, Sisi; Qi, Di; Chen, Kewei; Zhang, Zhanjun; Dysfunctional organization of default mode network before memory impairments in type 2 diabetes. , Psychoneuroendocrinology, 2016, 74: 141-148.