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  • BNU“京师学堂”脑科学前沿系列讲座第五十六讲
    Thalamic control of learning and memory
    Dr. Xiaoke Chen(陈晓科),Assistant Professor
    Department of Biology, Stanford University
    Dr. Xiaoke Chen2005年在中科院神经科学研究所获神经生物学博士学位;2006-2012分别在美国加州大学圣地亚戈分校和哥伦比亚大学 Charles Zuker教授实验室从事博士后研究。2013年始,在斯坦福大学生物学系建立自己的独立实验室,主要研究动机行为(motivated behaviors)生成和调控的大脑环路机制、以及慢性疼痛、成瘾和抑郁等神经精神疾病中动机行为相关环路的功能异常变化机制。研究发现发表于NatureScienceNature Neuroscience等国际知名学术期刊。
    报告摘要:Contemporary learning theorist hypothesized that both prediction error (PE) and stimulus salience are important for associative learning.  The role of PE in learning has been well documented thanks to the identification of PE coding in dopamine neurons.  However, the contribution of stimulus salience to learning has not been directly tested. In this talk, I will present new data support a critical role of neurons in the paraventricular nucleus of the thalamus (PVT) in gating the associative learning by providing a dynamic representation of stimulus salience. Furthermore, I will discuss how PVT can orchestrate the formation and maintenance of drug-associate memory via its connection to different downstream targets.