融合无创脑成像、认知行为实验、心理生理和基因及环境等多交叉学科技术,以正常、亚正常、临床异常儿童青少年至成人为研究对象,采用多维度模块化的组织方式,致力于揭示情绪如应激与焦虑对脑认知功能(如学习记忆与执行功能)的调节及障碍机制、以及情绪对儿童青少年脑发育与认知发展的影响规律及相关障碍。
代表性研究成果:
Brain systems and networks underlying human emotion and learning/memory under stress
LIU Y, LIN W, LIU C, WU J, LUO Y, BAYLEY P,
QIN S* (2016). Memory consolidation reconfigures neural pathways involved in suppression of emotional memories.
Nature Communications 7: 13375. doi:
10.1038/ncomms13375
QIN S*, HERMANS EJ, VAN MARLE HJG, FERNANDEZ G (2012). Understanding low reliability of memories for neutral information encoded under stress: alterations in memory-related activation in the hippocampus and midbrain.
The Journal of Neuroscience 32 (12): 4032-4041.
QIN S*, COUSIJN H, RIJPKEMA M, LUO J, FRANKE B, HERMANS EJ, FERMANDEZ G (2012). The effect of moderate psychological stress on working memory-related neural activity is modulated by a genetic variation in catecholaminergic function in humans.
Frontiers in integrative neuroscience 6: 1-16.
COUSIJN H, RIJPKEMA M,
QIN S, VAN MARLE HJF, FRANKE B, HERMANS EJ, VAN WINGEN GA, FERMANDEZ G (2010) Acute stress modulates genotype effects on amygdala processing in humans.
Proceedings of the National Academy of Sciences 107 (21): 9867-9872
HERMANS EJ, VAN MARLE HJF#, OSSEWAARDE L#, HENCKENS MJAG#,
QIN S#, VAN KESTEREN M#, SCHOOTS VC, COUSIJN H, RIJPKEMA M, OOSTENVELD, GERNANDEZ G (2011).
Stress-related noradrenergic activity prompts large-scale neural network reconfiguration. Science, 334 (6059): 1151-1153 (#Equal contribution)
QIN S*, VAN MARLE HJF, HERMANS EJ, FERNANDEZ G (2011) Subjective sense of memory strength and the objective amount of information accurately remembered are related to distinct neural correlates at encoding
. The Journal of Neuroscience 31 (24): 8920-8927
.
QIN S*, HERMANS EJ, VAN MARLE HJF, LUO J, FERNANDEZ G (2009). Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex.
Biological psychiatry 66 (1): 25-32.
QIN S, RIJPKEMA M, TENDOLKAR I, PIEKEMA C, HERMANS EJ, BINDER M, PETERSON KM, FERNANDEZ G (2009). Dissecting medial temporal lobe contributions to item and associative memory formation.
Neuroimage 46 (3): 874-881.
QIN S, PIEKEMA C, PETERSSON KM, HAN B, LUO J, FERNANDEZ G (2007). Probing the transformation of discontinuous associations into episodic memory: an event-related fMRI study.
Neuroimage 38 (1): 212-222.
Brain systems and networks underlying children’s cognitive and affective development
QIN S, CHO S, ROSENBERG-LEE M, CHEN T, GEARY D, & MENON V (2014)
. Hippocampal-neocortical reorganization underlies children’s cognitive development.
Nature Neuroscience, 17 (9), 1263-1269.
QIN S, YOUNG CB, DUAN X, CHEN T, SUPEKAR K, & MENON V (2014). Amygdala subregional structure and functional connectivity predicts individual differences in anxiety during early childhood.
Biological Psychiatry 75(11): 892-900.
QIN S, YOUNG CB
, SUPEKAR K, UDDIN LD, & MENON V. (2013). Immature integration and segregation of emotion-related brain circuitry.
Proceedings of the National Academy of Sciences 109 (20): 7941-7946.
Evans TM, Kochalka J, Ngoon TJ, Wu SS,
Qin S, Battista C, Menon V (2015). Brain Structural Integrity and Intrinsic Functional Connectivity Forecast 6 Year Longitudinal Growth in Children's Numerical Abilities
The Journal of Neuroscience 35 (33), 11743-11750.